High-Speed Liquid Chromatography of Isoprenoid Quinones. I. : Separation of Homologues, Geometrical Isomers and Decomposition Products of Phylloquinone, Menaquinone-4 and Ubiquinone-10

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Other Title
  • イソプレノイドキノン類の高速液体クロマトグラフィー(第1報) : フィロキノン, メナキノン-4,ユビキノン-10の同族体, 幾何異性体および分解物の分離
  • イソプレノイドキノン類の高速液体クロマトグラフィ--1-フィロキノン,メナキノンー4,ユビキノンー10の同族体,幾何異性体および分解物の分離
  • イソプレノイドキノンルイ ノ コウソク エキタイ クロマトグラフィー 1 フィ

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Description

In an attempt to separate homologues, cis-trans isomers, and decomposition products of the isoprenoid quinones, phylloquinone, menaquinone-4, and ubiquinone-10, high-speed liquid chromatographic method was investigated. Homologues of the isoprenoid quinones could be separated by using Permaphase ODS with methanol-water or dioxane-water. In both mobile phases, the plot of log k'vs. the number of carbon atoms in the isoprenoid side chain gave a linear relationship. Separation of decomposition products of the isoprenoid quinones was also achieved using the same condition as above. In the case of phylloquinone and menaquinone-4, the plot of log VR of the decomposition products vs. percent modifier gave a linear relationship. cis-trans isomers of the isoprenoid quinones was separated using Zorbax SIL with isopropyl ether-n-hexane.

Journal

  • YAKUGAKU ZASSHI

    YAKUGAKU ZASSHI 97 (5), 486-494, 1977

    The Pharmaceutical Society of Japan

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