The Effect of Quaternary Ammoinum Compounds on Stomach Emptying

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  • 胃内容排出におよぼす4級アンモニウム塩の影響
  • イ ナイヨウ ハイシュツ ニ オヨボス 4キュウ アンモニウムエン ノ エイキ

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Abstract

Five quaternary ammonium salts administered orally did not influence the stomach emptying rate of phenol red. On the other hand, when these quaternary ammonium salts were administered subcutaneously, a retardation of stomach emptying rate was observed thirty minutes after oral administration of phenol red and its extent was given in the following order, isopropamide iodie>benzilonium bromide>benactyzine methobromide=anisotropine methobromide>propantheline bromide. The measurement of the stomach emptying rate may be practical and useful as one of the methods of screening tests for pharmacologic response, e.g., the anticholinergic effects of quaternary ammonium salts. Trichloroacetate administered subcutaneously did not cause a fall in the stomach emptying rate of phenol red but it accerelated the reducing effect of isopropamide iodide on the stomach emptying rate of phenol red.

Journal

  • YAKUGAKU ZASSHI

    YAKUGAKU ZASSHI 97 (7), 801-804, 1977

    The Pharmaceutical Society of Japan

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