Investigation of the Efficacy of an Administration Plan for Tazobactam/Piperacillin (TAZ/PIPC) and the Incidence of Kidney and Hepatic Disorders

Senba Mina, Isami Keisuke, Yamashita Katsuya, Tsumagari Kyouichi, Yamashina Takuya, Sasaki Eiji, Tsuruta Minako, Miyoshi Takanori, Kawamata Yosei, Kozono Aki

doi:10.1248/yakushi.17-00016

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タゾバクタム／ピペラシリン（TAZ／PIPC）投与時における用量調節の有効性と，腎及び肝機能障害の発現頻度
タゾバクタム/ピペラシリン(TAZ/PIPC)トウヨジニオケルヨウリョウチョウセツノユウコウセイト,ジンオヨビカンキノウショウガイノハツゲンヒンド

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Tazobactam/piperacillin (TAZ/PIPC) is widely used in the treatment of infectious disease. In this study, three hundred and sixty-three patients who were treated with the recommended dose of TAZ/PIPC were investigated for the proportion of time above the minimum inhibitory concentration (%TAM) and the frequency of renal and liver dysfunction. Of the whole patient population, 5.23%, exhibited increased creatinine levels, 9.37% and 8.82% exhibited increased aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels, respectively. The patients who exhibited high serum creatinine (SCr) levels before administration, exhibited significant increases of AST (p=0.0121). The patients who exhibited low albumin levels before administration, exhibited significant decreases in renal function (p=0.0041). In the case of a breakpoint (BP) of 64 μg/mL, the arrival probabilities of %TAM of 30% and 50% were 99.4% and 76.9%, respectively. We suggested that the dose of TAZ/PIPC should be adjusted according to the interview form finding and a %TAM>50% (maximal bactericidal action).<br>

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YAKUGAKU ZASSHI

YAKUGAKU ZASSHI 137 (10), 1277-1284, 2017-10-01

The Pharmaceutical Society of Japan

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