Evaluation of Clinical and Laboratory Findings of Pediatric and Adult Patients with Oropharyngeal Tularemia in Turkey: a Combination of Surgical Drainage and Antibiotic Therapy Increases Treatment Success

DOI Web Site PubMed 参考文献16件
  • Gozel Mustafa Gokhan
    Department of Infectious Diseases and Clinical Microbiology, Cumhuriyet University Faculty of Medicine
  • Engin Aynur
    Department of Infectious Diseases and Clinical Microbiology, Cumhuriyet University Faculty of Medicine
  • Altuntas Emine Elif
    Department of Otorhinolaryngology, Cumhuriyet University Faculty of Medicine
  • Salk İsmail
    Department of Radiology, Cumhuriyet University Faculty of Medicine
  • Kaya Ali
    Department of Pediatrics, Cumhuriyet University Faculty of Medicine
  • Celik Cem
    Department of Medical Microbiology, Cumhuriyet University Faculty of Medicine
  • Dokmetas Ilyas
    Department of Infectious Diseases and Clinical Microbiology, Cumhuriyet University Faculty of Medicine
  • Bakir Mehmet
    Department of Infectious Diseases and Clinical Microbiology, Cumhuriyet University Faculty of Medicine
  • Elaldi Nazif
    Department of Infectious Diseases and Clinical Microbiology, Cumhuriyet University Faculty of Medicine

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We analyzed the clinical and laboratory findings of both pediatric and adult patients with oropharyngeal tularemia. We also compared the therapeutic outcomes of patients who underwent surgical drainage of lymph nodes early or late during antibiotic therapy. A total of 68 patients with oropharyngeal tularemia, including 26 children and 42 adults, were enrolled in this study. The average duration between symptom onset and hospital admission was 20.8 days (4–60 days) in the pediatric group and 32.6 days (4–90 days) in the adult group (P = 0.009). The most frequently observed clinical symptoms were sore throat (100% and 100%), fever (96.2% and 90.5%), tonsillitis (69.2% and 78.6%), and rash (15.4% and 11.9%) in the pediatric and adult groups, respectively. However, the frequencies of erythema, tenderness, and fluctuant of enlarged lymph nodes were significantly higher in the adult group than in the pediatric group (P = 0.005, P = 0.029, and P = 0.041, respectively). Treatment failure was observed in 2 (7.7%) pediatric patients and 4 (9.5%) adult patients, for a total of 6 (8.8%) treatment failures in the study group. Similar clinical findings and treatment outcomes were observed in both groups. We concluded that a combination of surgical drainage and antibiotic therapy increases treatment success for patients diagnosed with oropharyngeal tularemia.

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