Antibiotic Susceptibilities and Genetic Characteristics of Extended-Spectrum Beta-Lactamase-Producing Escherichia coli Isolates from Stools of Pediatric Diarrhea Patients in Surabaya, Indonesia

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  • Bagus Wasito Eddy
    Department of Microbiology, Faculty of Medicine, Airlangga University/Dr. Soetomo Hospital Institute of Tropical Disease, Airlangga University
  • Shigemura Katsumi
    Department of Urology, Kobe University Graduate School of Medicine Indonesia-Japan Collaborative Research Center for Emerging and Re-emerging Infectious Diseases, Institute of Tropical Disease, Airlangga University Division of Infectious Diseases, Department of International Health, Kobe University Graduate School of Health Science
  • Osawa Kayo
    Indonesia-Japan Collaborative Research Center for Emerging and Re-emerging Infectious Diseases, Institute of Tropical Disease, Airlangga University Division of Infectious Diseases, Department of International Health, Kobe University Graduate School of Health Science
  • Fardah Alpha
    Department of Pediatrics, Faculty of Medicine, Airlangga University
  • Kanaida Akiho
    Division of Infectious Diseases, Department of International Health, Kobe University Graduate School of Health Science
  • Raharjo Dadik
    Indonesia-Japan Collaborative Research Center for Emerging and Re-emerging Infectious Diseases, Institute of Tropical Disease, Airlangga University Institute of Tropical Disease, Airlangga University
  • Kuntaman K.
    Department of Microbiology, Faculty of Medicine, Airlangga University/Dr. Soetomo Hospital Indonesia-Japan Collaborative Research Center for Emerging and Re-emerging Infectious Diseases, Institute of Tropical Disease, Airlangga University
  • Hadi Usman
    Department of Internal Medicine, Faculty of Medicine, Airlangga University/Dr. Soetomo Hospital
  • Harijono Sugeng
    Indonesia-Japan Collaborative Research Center for Emerging and Re-emerging Infectious Diseases, Institute of Tropical Disease, Airlangga University Institute of Tropical Disease, Airlangga University
  • Marto Sudarmo Subijanto
    Department of Pediatrics, Faculty of Medicine, Airlangga University
  • Nakamura Tatsuya
    Department of Clinical Laboratory, Kobe University Hospital
  • Shibayama Keigo
    Department of Bacteriology II, National Institute of Infectious Diseases
  • Fujisawa Masato
    Department of Urology, Kobe University Graduate School of Medicine
  • Shirakawa Toshiro
    Indonesia-Japan Collaborative Research Center for Emerging and Re-emerging Infectious Diseases, Institute of Tropical Disease, Airlangga University Center for Infectious Diseases, Kobe University Graduate School of Medicine

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  • Antibiotic Susceptibilities and Genetic Characteristics of Extended-Spectrum Beta-Lactamase-Producing <i>Escherichia coli</i> Isolates from Stools of Pediatric Diarrhea Patients in Surabaya, Indonesia

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<p>The purpose of this study was to investigate extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli isolates from pediatric (aged 0 to 3 years) diarrhea patients in Surabaya, Indonesia, where this kind of survey is rare; our study included assessment of their antibiotic susceptibilities, as well as ESBL typing, multilocus sequence typing (MLST), and diarrheagenic E. coli (DEC)-typing. ESBL-producing E. coli were detected in 18.8% of all the samples. Many ESBL-producing E. coli had significantly lower susceptibility to gentamicin (p ＜ 0.0001) and the quinolones nalidixic acid (p＝0.004) and ciprofloxacin (p ＜ 0.0001) than non-producers. In ESBL-producing E. coli, 84.0% of strains expressed CTX-M-15 alone or in combination with other ESBL types. MLST revealed that 24.0% of ESBL-producers had sequence type 617, all of which expressed the CTX-M-15 gene; we also detected expression of 3 DEC-related genes: 2 enteroaggregative E. coli genes and 1 enteropathogenic E. coli gene. In conclusion, CTX-M-15-type ESBL-producing E. coli ST617 appear to have spread to Indonesia.</p>

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