A SUGGESTED ROLE OF THE LYSOSOMAL MEMBRANE AS A PART OF THE DEFENCE MECHANISM AGAINST TUBERCULOUS INFECTION

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A large-molecular complex fraction associating with cathepsin and acid phosphatase activities was separated from a detergent-extract of the lysosomal pellet of lungs by gel-filtration. When the fraction was obtained from“BCG-stimulated”animals, it showed antimycobacterial activities. The corresponding fraction from normal animals did not. By further fractionation, the complex was separated into 5 subfractions; hydrophobic protein, phospholipid, neutral fat, free fatty acid and water-soluble peptide fractions. The antimycobacterial activities were attributed to the last two subfractions. The corresponding subfractions from the inactive complex of normal animals were also antimycobacterial. These observations, together with those reported in the accompanying paper, led us to a view that the lysosmal membrane might be a site of the host-parasite interaction, and that a change in the orientation of membrane components caused by infection or allergic reaction produces a situation that the intracellular bacilli might come into contact with such antibacterial molecules. However, other possibilities were not excluded.

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