Predominance of Serogroup 19 CC320/271 among Penicillin-Nonsusceptible <i>Streptococcus pneumoniae</i> Isolates after Introduction of the PCV7 Vaccine in Several Regions of Japan
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- Oodate Mitsuru
- Department of Bacteriology, Nagoya University Graduate School of Medicine Department of Respiratory Medicine, Nagoya University Graduate School of Medicine
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- Kimura Kouji
- Department of Bacteriology, Nagoya University Graduate School of Medicine
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- Banno Hirotsugu
- Department of Bacteriology, Nagoya University Graduate School of Medicine
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- Yokoyama Satoru
- Department of Bacteriology, Nagoya University Graduate School of Medicine
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- Jin Wanchun
- Department of Bacteriology, Nagoya University Graduate School of Medicine
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- Wachino Jun-ichi
- Department of Bacteriology, Nagoya University Graduate School of Medicine
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- Hasegawa Yoshinori
- Department of Respiratory Medicine, Nagoya University Graduate School of Medicine
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- Arakawa Yoshichika
- Department of Bacteriology, Nagoya University Graduate School of Medicine
Bibliographic Information
- Other Title
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- Predominance of Serogroup 19 CC320/271 among Penicillin-Nonsusceptible Streptococcus pneumoniae Isolates after Introduction of the PCV7 Vaccine in Several Regions of Japan
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Abstract
<p>Multidrug-resistant Streptococcus pneumoniae serogroup 19, including serotypes 19A and 19F, associated with clonal complex 320/271 (CC320/271), has been previously shown to be predominant in many countries after introduction of a 7-valent pneumococcal conjugate vaccine (PCV7). However, in Japan there has been no epidemiological research focused on penicillin-nonsusceptible isolates after this event. Therefore, we aimed to characterize penicillin-nonsusceptible S. pneumoniae (PNSSP; penicillin minimum inhibitory concentration [MIC] ≥ 4.0 μg/ml) after the introduction of PCV7 in Japan. Throughout Japan, we collected 1,057 pneumococcal isolates from 2010 to 2014. We then evaluated MICs and performed serotyping, multilocus sequence typing, and sequencing of penicillin-binding protein genes in 51 isolates (penicillin MIC ≥ 2.0 μg/ml). Twenty-three isolates (2.2%) showed penicillin nonsusceptibility (penicillin MIC ≥ 4.0 μg/ml). Serotypes 19F (14 isolates, 60.9%) and 23F (4 isolates, 17.4%), which are covered by the vaccine, were predominant among PNSSP strains. Only 3 isolates belonged to nonvaccine serotype 19A. Among the PNSSP isolates, CC320/271 (16/23 strains, 69.6%) was the most prevalent clone. Moreover, CC320/271 clones showed high MIC values of a third-generation cephalosporin. Thus, we demonstrated clonal predominance of serogroup 19 CC320/271 with strong resistance to β-lactams including a third-generation cephalosporin among PNSSP isolates.</p>
Journal
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- Japanese Journal of Infectious Diseases
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Japanese Journal of Infectious Diseases 71 (1), 14-20, 2018
National Institute of Infectious Diseases, Japanese Journal of Infectious Diseases Editorial Committee
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Details 詳細情報について
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- CRID
- 1390282681217304704
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- NII Article ID
- 130006317355
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- NII Book ID
- AA1132885X
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- ISSN
- 18842836
- 13446304
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- NDL BIB ID
- 028792303
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- PubMed
- 29093321
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed