Antimycobacterial activity of lecithin-cholesterol liposomes in the presence of phospholipase A2
書誌事項
- タイトル別名
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- ANTIMYCOBACTERIAL ACTIVITY OF LECITHIN-CHOLESTEROL LIPOSOMES IN THE PRESENCE OF PHOSPHOLIPASE A<SUB>2</SUB>
- Antimycobacterial activity of lecithin
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説明
Tubercle bacilli were preincubated with lecithin-cholesterol liposomes to be subsequently exposed to phospholipase A2. After further incubation in the environment of acidic buffer, viable units in the final mixture were enumerated by inoculating the serial dilutions of an aliquot onto Kirchner agar medium containing horse serum in 5%. Another aliquot was used for lipid analyses to confirm hydrolysis of lecithin. In addition to this bactericidal type of experiments, bacteriostatic tests were also conducted with Kirchner semi-solid agar medium, into which liposome-treated bacilli were inoculated with the enzyme at a time. Various natural and synthetic lecithins different in constituent fatty acids were employed. The results indicated that toxic fatty acids released from lecithin acted to kill the bacilli or to inhibit their growth.
収録刊行物
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- Ｊａｐａｎｅｓｅ Ｊｏｕｒｎａｌ ｏｆ Ｍｅｄｉｃａｌ Ｓｃｉｅｎｃｅ ａｎｄ Ｂｉｏｌｏｇｙ
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Ｊａｐａｎｅｓｅ Ｊｏｕｒｎａｌ ｏｆ Ｍｅｄｉｃａｌ Ｓｃｉｅｎｃｅ ａｎｄ Ｂｉｏｌｏｇｙ 31 (3), 249-262, 1978
国立感染症研究所 Japanese Journal of Infectious Diseases 編集委員会
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詳細情報 詳細情報について
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- CRID
- 1390282681217340288
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- NII論文ID
- 130003953273
- 40005305494
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- NII書誌ID
- AA1132885X
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- COI
- 1:CAS:528:DyaE1cXlslCgur8%3D
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- ISSN
- 18842828
- 00215112
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- NDL書誌ID
- 1945648
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- PubMed
- 32413
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可