Incidence of Intussusception as Studied from a Hospital-Based Retrospective Survey over a 10-Year Period (2001–2010) in Akita Prefecture, Japan
-
- Noguchi Atsuko
- Department of Pediatrics, Akita University Graduate School of Medicine
-
- Nakagomi Toyoko
- Division of Molecular Epidemiology, Graduate School of Biomedical Sciences, and Global Center of Excellence, Nagasaki University
-
- Kimura Shigeru
- Akita Red Cross Hospital
-
- Takahashi Yoshihiro
- Odate Municipal Hospital
-
- Matsuno Kenichi
- Oga Minato Municipal Hospital
-
- Koizumi Hiromi
- Akita City Hospital
-
- Watanabe Arata
- Nakadori General Hospital
-
- Noguchi Hiroo
- Kita-Akita Municipal Hospital
-
- Ito Tadahiko
- Hiraka General Hospital
-
- Ohtsuka Mihoko
- Akita Social Insurance Hospital
-
- Uemura Naoya
- Yamamoto-Kumiai General Hospital
-
- Takeda Osamu
- Koto General Hospital
-
- Komatsu Akira
- Yokote Municipal Hospital
-
- Kikuchi Wataru
- Ogachi Central Hospital
-
- Komatsu Masaki
- Akita-Kumiai General Hospital
-
- Fukaya Hiroshi
- Senboku-Kumiai General Hospital
-
- Miura Shinobu
- Yuri-Kumiai General Hospital
-
- Toda Hiroyuki
- Kazuno-Kosei Hospital
-
- Nakagomi Osamu
- Division of Molecular Epidemiology, Graduate School of Biomedical Sciences, and Global Center of Excellence, Nagasaki University
-
- Takahashi Tsutomu
- Department of Pediatrics, Akita University Graduate School of Medicine
Bibliographic Information
- Other Title
-
- Incidence of Intussusception as Studied from a Hospital-Based Retrospective Survey over a 10-Year Period (2001^|^ndash;2010) in Akita Prefecture, Japan
Search this article
Abstract
One concern about rotavirus vaccines is its possible association with intussusception. Thus, it is necessary to determine the baseline incidence for intussusception in the first year of life in places where rotavirus vaccines are introduced. However, few safety data exist for the period at which the first dose of Rotarix and RotaTeq are allowed to administer in Japan. The first dose of Rotarix is scheduled to administer at 6–20 weeks of age and that of RotaTeq is scheduled to administer at 6–24 weeks of age; the upper limits for these vaccines is later than the upper limit recommended by the World Health Organization by 5 and 9 weeks, respectively. We performed a retrospective cross-sectional study by reviewing medical charts of all hospitals that provided pediatric beds in Akita Prefecture, Japan, and identifying the cases of intussusception that met the Brighton criteria level 1 in these hospitals between January 2001 and December 2010. During this 10-year period, 122 children younger than 1 year of age were diagnosed with intussusception. The incidence of intussusception was estimated at 158 per 100,000 person-years among children younger than 1 year (95% confidence interval, 131–188), 10 per 100,000 person-years for children aged 0–2 months, 165 for children aged 3–5 months, and 300 for children aged 6–8 months. This rapid and substantial increase in the incidence of intussusception during the first year of life should be considered when formulating the immunization schedule for administering rotavirus vaccines in Japan.
Journal
-
- Japanese Journal of Infectious Diseases
-
Japanese Journal of Infectious Diseases 65 (4), 301-305, 2012
National Institute of Infectious Diseases, Japanese Journal of Infectious Diseases Editorial Committee
- Tweet
Keywords
- Rotavirus vaccine
- child health
- controlled study
- cross-sectional study
- disease surveillance
- drug effect
- drug safety
- health survey
- hospital planning
- human
- infant
- intussusception
- Japan
- major clinical study
- medical record review
- population research
- review
- trend study
- vaccination
- Cross-Sectional Studies
- Humans
- Incidence
- Infant, Newborn
- Intussusception
- Retrospective Studies
- Rotavirus Vaccines
Details 詳細情報について
-
- CRID
- 1390282681218001536
-
- NII Article ID
- 130001931826
-
- NII Book ID
- AA1132885X
-
- ISSN
- 18842836
- 13446304
-
- HANDLE
- 10069/30515
-
- NDL BIB ID
- 023840515
-
- PubMed
- 22814151
-
- Text Lang
- en
-
- Data Source
-
- JaLC
- IRDB
- NDL
- Crossref
- PubMed
- CiNii Articles
-
- Abstract License Flag
- Disallowed