Effects of Ribavirin on Severe Fever with Thrombocytopenia Syndrome Virus In Vitro

DOI Web Site PubMed 被引用文献18件 参考文献33件 オープンアクセス
  • Shimojima Masayuki
    Special Pathogens Laboratory, Department of Virology I, National Institute of Infectious Diseases
  • Fukushi Shuetsu
    Special Pathogens Laboratory, Department of Virology I, National Institute of Infectious Diseases
  • Tani Hideki
    Special Pathogens Laboratory, Department of Virology I, National Institute of Infectious Diseases
  • Yoshikawa Tomoki
    Special Pathogens Laboratory, Department of Virology I, National Institute of Infectious Diseases
  • Fukuma Aiko
    Special Pathogens Laboratory, Department of Virology I, National Institute of Infectious Diseases
  • Taniguchi Satoshi
    Special Pathogens Laboratory, Department of Virology I, National Institute of Infectious Diseases Department of Biomedical Science, Graduate School of Agricultural and Life Sciences, University of Tokyo
  • Suda Yuto
    Special Pathogens Laboratory, Department of Virology I, National Institute of Infectious Diseases Department of Veterinary Microbiology, Graduate School of Agricultural and Life Sciences, University of Tokyo
  • Maeda Ken
    Laboratory of Veterinary Microbiology, Faculty of Agriculture, Yamaguchi University
  • Takahashi Toru
    Department of Hematology, Yamaguchi Grand Medical Center
  • Morikawa Shigeru
    Department of Veterinary Science, National Institute of Infectious Diseases
  • Saijo Masayuki
    Special Pathogens Laboratory, Department of Virology I, National Institute of Infectious Diseases

この論文をさがす

抄録

Severe fever with thrombocytopenia syndrome (SFTS) is a disease with a high case fatality rate that is caused by infection with the recently identified tick-borne SFTS virus (SFTSV), for which there are no specific countermeasures. We examined the effects of ribavirin and mizoribine, which are nucleoside analogue drugs with broad antiviral activities, on SFTSV proliferation in vitro. When 3 cell lines were treated with these drugs before and during infection with a Chinese SFTSV strain, the 99% effective concentrations (EC99) of ribavirin were 19–64 μg/ml (78–262 μM); in contrast, the EC99 of mizoribine was >500 μg/ml (1,929 μM). Similar levels of inhibitory effects of ribavirin were observed with 4 Japanese SFTSV strains. However, when Vero cells were treated with ribavirin 3 days after inoculation, the inhibitory effect was dramatically decreased, indicating that ribavirin did not effectively reduce virus production in pre-infected cells. These results suggest that ribavirin could be used as post-exposure prophylaxis for the prevention of SFTS.

収録刊行物

被引用文献 (18)*注記

もっと見る

参考文献 (33)*注記

もっと見る

関連プロジェクト

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ