Ticarcillinの基礎的・臨床的研究

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タイトル別名
  • LABORATORY AND CLINICAL STUDIES ON TICARCILLIN
  • Ticarcillin ノ キソテキ リンショウテキ ケンキュウ

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Ticarcillin is a new semi-synthetic penicillin with structure similar to that of CBPC.<BR>1) The antibacterial spectrum of ticarcillin is almost the same with that of CBPC and its antibacterial activity is stronger than that.<BR>2) The absorption and excretion of ticarcillin is also almost the same with that of SBPC. The serum concentration in 2 patients with bronchiectasia following 3. 0 g drip infusion was around 100 μg/ml at the end of D. I. and the sputum level was respectively 6. 8 and 14. 0 μg/ml at 2 hours in D. I..<BR>3) Ticarcillin was administered to 6 patients with respiratory tract infection and one patient with urinary tract infection at a daily dose of 6.0 g during 6-15 days. As the result, overall clinical response was good in 4 cases and bacteriological effect was good in 3 cases. These clinical results may be as well from the antibacterial activity, absorption and excretion of ticarcillin.<BR>From above, ticarcillin has stronger antibacterial activity than CBPC and it may have an availability in the infection due to Ps. aeruginosa with low toxicity and mass medication.

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