EXPERIMENTAL AND CLINICAL STUDIES ON HEXAMINE MANDELATE IN RECURRENT URINARY TRACT INFECTIONS

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  • 反復性尿路感染症に対するHexamine Mandelateの基礎的臨床的検討
  • ハンプクセイ ニョウロ カンセンショウ ニ タイスル Hexamine mandelate ノ キソテキ リンショウテキ ケントウ

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Abstract

For the purpose of studies on prevention of recurrent urinary tract infections, effect of hexamine (Methenamine) mandelate was evaluated to the infections in vitro and in vivo. <BR>Ascorbic acid was considered to be a suitable urine acidifying drug that enhances the activity of hexamine mandelate. The considerable amount of formaldehyde (average 308.3 mcg per ml) was detected in the urine following the administration of hexamine mandelate and ascorbic acid. The concentration was enough to inhibit growth of the various causative organisms in the infections ; that is, bactericidal against E. coli, Proteus, and Klebsiella, whereas bacteriostatic against Pseudomonas.<BR>Hexamine mandelate (4 g/day) and ascorbic acid (3.2 g/day) were administrated daily to 19 patients with recurrent urinary tract infections followed by injury of the spinal cord in the periods ranging from 6 to 30 months. The number of fever attacks of the patients were decreased significantly by the administration, accompanying less necessity of the usage of antibiotics.<BR>Hexamine mandelate and ascorbic acid appeared to be effective prophylaxis agent in recurrent urinary tract infection with low incidence of side effects.

Journal

  • CHEMOTHERAPY

    CHEMOTHERAPY 21 (6), 1213-1220, 1973

    Japanese Society of Chemotherapy

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