Carbenicillinの基礎的・臨床的研究

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タイトル別名
  • LABORATORY AND CLINICAL STUDIES OF CARBENICILLIN
  • Carbenicillin ノ キソテキ リンショウテキ ケンキュウ

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1) The activity distribution of carbenicillin against clinical pathogenic isolates from the respiratory airway (1968. Feb. -June) was measured. All pathogenic Staphylococci (26 strains) were inhibited by 1. 6 ->100 mcg/ml. The strong correlation of carbenicillin and penicillin G against staphylococci w as found, but some high resistant strains to penicillin G were low resistant to carbenicillin. All B. Klebsiella (6 strains) were inhibited by >100 mcg/ml, but Pseudomonas aeruginosa was inhibited by 50 -250 mcg/ml. 2) The b lood peak level (37-48 mcg/ml) of carbenicillin obtained in one hour after 1. 0 g intramuscular injection and the blood titer of two cases of normal renal function were 1/2 five hours after but the high renal failure case showed a 10 mcg/ml level down than the peak titer twelve hours after. The blood peak level in the two cases of intravenous drop administration of carbenicillin 8. 0 g in 500 ml 5 % glucose solution was 300-340 mcg/ml and the sputum level was 2-3 mcg/ml. 3) Rat tissue assays showed the peak titer of each tissue obtained in a ha lf hour after intramuscular injection and kidney had the highest activity of carbenicillin and other tissues were in the following order, liver, lung and blood. Especially the high activity of lung was found for long hours. 4) Our clinical cases were seven. In the H. influenzae bronchobronchiolitis, good resu lt was obtained by the intravenous drop administration of carbenicillin 8. 0 g. Neither side effect nor toxicity of carbenicillin was found.

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