THE TOXIC EFFECT OF DKB (3', 4'-DIDEOXYKANAMYCIN B) ON THE INNER EAR

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  • NAKAI YOSHIAKI
    Department ot Otolaryngology, Osaka City University Medical School
  • YAMAMOTO KAORU
    Department ot Otolaryngology, Osaka City University Medical School
  • IWAMOTO TSUTOMU
    Department ot Otolaryngology, Osaka City University Medical School
  • KANEKO MINORU
    Department ot Otolaryngology, Osaka City University Medical School
  • KUGA RYUICHI
    Department ot Otolaryngology, Osaka City University Medical School

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Other Title
  • DKB (3', 4'-Dideoxykanamycin B) の内耳毒性に関する実験的研究
  • DKB 3 , 4 -Dideoxykanamycin B ノ ナイジ ドクセイ ニ カンスル ジッケンテキ ケンキュウ

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Abstract

The toxic action of DKB on mice was studied with special regard to the ototoxic action. DKB was found to be more toxic than vistamycin, same toxic as kanamycin, kanendomycin, but less toxic than gentamicin with regard to toxicity/g/body weight.<BR>Toxic reactions were observed in the cochlear and vestibular sensory epithelia with more severe reactions in the cochlear than the vestibular system.<BR>Degeneration appeared first in the outer hair cells in the basal turn of the cochlea starting with the increasing of lysosomes, degeneration of mitochondria in the subcuticle area and resulting in the complete loss of hair cells, but stria vascularis and spiral ligament showed little change.<BR>Severe changes were observed in the sensory epithelium of the cristae ampullares and utricular maculae. Early changes with hair swelling and fusion, degeneration of mitochondria and ballooning of the cell surface were observed leading to complete degeneration first of the type I and later of the type II hair cells.

Journal

  • CHEMOTHERAPY

    CHEMOTHERAPY 22 (5), 1000-1006, 1974

    Japanese Society of Chemotherapy

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