COMPARISON OF <I>IN VITRO</I> ANTIBACTERIAL ACTIVITY BETWEEN SF-837 (MYDECAMYCIN) AND OTHER MACROLIDE ANTIBIOTICS
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- KOIKE MASAATSU
- Department of Oral Bacteriology, Faculty of Dentistry, Kyushu University
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- NAGAYAMA ARIAKI
- Department of Oral Bacteriology, Faculty of Dentistry, Kyushu University
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- IIDA KYOKO
- Department of Oral Bacteriology, Faculty of Dentistry, Kyushu University
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- NAKASHIMA KOICHI
- Department of Oral Bacteriology, Faculty of Dentistry, Kyushu University
Bibliographic Information
- Other Title
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- SF-837 (ミデカマイシン) と他のMacrolide系抗生物質との<I>in vitro</I>抗菌力の比較
- SF-837 ミデカマイシン ト タ ノ Macrolideケイ コウセイブツシツ ト ノ in vitro コウキンリョク ノ ヒカク
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Abstract
The comparison was made on the antibacterial activity of SF-837 and other macrolide antibiotics against 96 strains of Staphylococcus aureus isolated clinically, as well as the cross resistance was investigated.<BR>The MIC of SF-837 was distributed among 0.8-3.1 mcg/ml, and the peak was recognized at 1.5 mcg/ml. Fourteen strains showed an MIC even at >100 mcg/ml. The MIC of SF-837 was almost the same as that of JM (josamycin) or LM (leucomycin).<BR>The cross resistance was investigated between SF-837 and LM, EM (erythromycin), MJ and Acetyl-SPM (acetyl-spiramycin) respectively. The results obtained demonstrated that a correlation exists between SF-837 and each other drug. The resistant strains of >100 mcg/ml were noticed at the ratio of 14-15% with each antibiotic.
Journal
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- CHEMOTHERAPY
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CHEMOTHERAPY 21 (4), 720-724, 1973
Japanese Society of Chemotherapy
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Details 詳細情報について
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- CRID
- 1390282681255047936
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- NII Article ID
- 130004070719
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- NII Book ID
- AN00186653
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- ISSN
- 18845894
- 00093165
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- NDL BIB ID
- 7493871
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- Data Source
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- JaLC
- NDL
- CiNii Articles
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- Abstract License Flag
- Disallowed