イミダゾール系抗真菌剤ミコナゾールが奏効したカンジダ敗血症例と考察
書誌事項
- タイトル別名
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- A CASE OF <I>CANDIDA ALBICANS</I> SEPTICEMIA WITH GOOD PROCESS TREATED WITH A NEW ANTIFUNGAL AGENT, MICONAZOLE
説明
We have presented a case of Candida albicans septicemia which was cured with an antifungal imidazole derivative, miconazole, together with a few discussions.<BR>In this case, a 32-year-old man was operated on by rectectomy for colonic polyp. While he was under management by IVH, a high fever appeared, with C. albicans isolated from the venous blood, arterial blood and myelic blood. He was then treated with 800 to 1, 200mg daily of miconazole, every day, for 33 days (to a total dose of 30.2g), ran a favorable course, and was eventually' discharged. The treatment was associated with no side effects of the drug. The MICs of miconazole for the isolates were in the range from 0.39 to 0.78 μg/ml, and the blood level of the drug reached a peak of 0.90 μ g/ml following the administration of 400mg of the drug.<BR>We also compared the antibacterial activities of amphotericin B (AMPH), miconazole and 5-fluorocytosine (5-FC) against the 29 recent isolates of C. albicans from clinical materials. The antibacterial activity of AMPH was comparable to that of miconazole, with their MICs for the isolates distributed in the range of not more than 1.56 μ g/ml. The antibacterial activity of 5-FC was not as potent as those of the former.<BR>Because miconazole has proved to have a potent antibacterial activity, accompanied by a low incidence of side effects, we think that this drug will be a useful therapeutic agent for deep candidiasis.
収録刊行物
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- ＣＨＥＭＯＴＨＥＲＡＰＹ
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ＣＨＥＭＯＴＨＥＲＡＰＹ 32 (6), 365-370, 1984
公益社団法人 日本化学療法学会
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詳細情報 詳細情報について
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- CRID
- 1390282681255533696
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- NII論文ID
- 130004194303
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- ISSN
- 18845894
- 00093165
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可
