BACTERIOLOGICAL STUDIES ON AMINODEOXYKANAMYCIN, A NEW BASIC AND WATER-SO L UBLE ANTIBIOTIC

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  • GOTO SACHIKO
    Department of Microbiology, Toho University, School of Medicine, Tokyo
  • KUWAHARA SHOGO
    Department of Microbiology, Toho University, School of Medicine, Tokyo
  • ABE MASAHIRO
    Department of Pharmaceutical Products Development, Kawasaki Plant, Meiji Seika Kaisha, Ltd., Kawasaki
  • KAWASAKI TOYOAKI
    Department of Pharmaceutical Products Development, Kawasaki Plant, Meiji Seika Kaisha, Ltd., Kawasaki
  • NOMITA BUNZO
    Pathology and Pathogenic Microbiology Section, Research Laboratories, Meiji Seika Kaisha, Ltd., Yokohama

Bibliographic Information

Other Title
  • Aminodeoxykanamycin(2'-Amino-2'-deoxy-kanamycin)の細菌学的研究
  • Aminodeoxykanamycin 2 -Amino-2 -deoxy-kanamycin ノ サイキンガクテキ ケンキュウ

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Abstract

In vitro and in vivo studies on the anti-microbial action of 2′-amino-2′-deoxy-kanamycin (AKM) have been carried out and the following results were obtained:<BR>1) AKM was found broadly effective against Gram positive or negative, acid-fast bacilli, but was ineffective against facultive or obligate anaerobic bacteria, fungi and protozoa. The antibacterial spectrum of AKM was the same as that of kanamycin.<BR>2) The anti-bacterial activity of AKM a gainst the susceptible strains except those of acid-fast bacilli was no more or more than that of kanamycin and its minimum inhibitory concentration was within the range of one second and eighth of kanamycin. On the contrary, in the case of acid-fast bacilli, its minimum inhibitory concentration was the same or a little less than that of kanamycin.<BR>3) It was confirmed that there would be the distinct cross-resistance between AKM and kanamycin<BR>4) AKM was shown to lose its anti-bacterial activity in the medium with acidity of le ss than 6. 0 of pH value, and with larger size of inocula.<BR>5) In the studies with mice experi mentally infected with Staphylococcuasu reus, Diplococcusp n eumoniae, Klebsiellap neumoniae, and Proteus vulgaris, AKM showed the curative effects which were par allel with its minimum inhibitory concentration values, its ED50 being found no more or less than that of kanamycin.

Journal

  • CHEMOTHERAPY

    CHEMOTHERAPY 17 (9), 1641-1649, 1969

    Japanese Society of Chemotherapy

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