じん機能障害時におけるセホタキシムの動態および代謝に関する研究

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タイトル別名
  • PHARMACOKINETICS OF CEFOTAXIME AND DESACETYL CEFOTAXIME IN NORMAL SUBJECTS AND PATIENTS WITH IMPAIRED RENAL FUNCTION
  • ジン キノウ ショウガイジ ニ オケル Cefxtaxime ノ ドウタイ オ

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The pharmacokinetics of cefotaxime (CTX), a new semi-synthesized cephalosporin antibiotic for injection, was studied in 7 normal volunteers and 23 patients with impaired renal function after a single 1-gram intramuscular injection. Serum and urinary concentrations of CTX and desacetyl CTX were determined by high pressure liquid chromatography. The pharmacomacokinetic parameters of CTX were obtained by analyzing the serum level data of CTX based on a one-compartment open model. The mean peak serum concentrations of CTX and descetyl CTX were 26.3 and 3.2μg/ml in normal subjects, respectively. There was a significant linear correlation (p<0.001) between the elimination rate constant of CTX and the creatinine clearance. The mean serum half-life of CTX was calculated as 52 minutes in normal subjects; the half-life increased in patients parallel with the degree of renal impairment. The mean cumulative urinary recovery of the administred dose in the 24-hour urine was 51.7 per cent as CTX and 25.6 per cent as desacetyl CTX in normal subjects. As renal function declined, the urinary excretion of both CTX and desacetyl CTX decreased.

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