In vitro synergistic effect of aminoglycosides and .BETA.-lactams.

DOI

Bibliographic Information

Other Title
  • アミノ配糖体系抗生物質とβ‐ラクタム系抗生物質とのｉｎ　ｖｉｔｒｏ併用効果について

Abstract

The in vitro combined action of aminoglycosides (AGs), isepamicin (ISP) or netilmicin (NTL), with β-lactams, flomoxef (FMOX) or imipenem/cilastatin sodium (IPM/CS), was studied against Escherichia coli, Serratia marcescens, Pseudomonas aeruginosa and methicillin-resistant Staphylococcus aureus. The following results were obtained:<BR>1. The antibacterial activity of each antibiotic by itself against E. coli was strong.<BR>2. Synergistic action of ISP or NTL with FMOX or IPM/CS was observed in all bacteria, especially S. marcescens. The combination of ISP with FMOX was most effective (mean minimum FIC index: 0.272).<BR>3. With each combination bactericidal activity was observed in S. marcescens T-55 at concentrations in which the respective drugs alone showed only bacteriostatic activity.<BR>4. Phase-contrast microscopic observation of S. marcescens T-55 demonstrated that the bacterial cells treated with FMOX showed a filament-like form, those treated with IPM/CS a spherical form and those treated with ISP or NTL almost a normal form. With each combination lysed cells were observed.

Journal

  • CHEMOTHERAPY

    CHEMOTHERAPY 37 (11), 1327-1333, 1989

    Japanese Society of Chemotherapy

Keywords

Details 詳細情報について

  • CRID
    1390282681256041344
  • NII Article ID
    130004196693
  • DOI
    10.11250/chemotherapy1953.37.1327
  • ISSN
    18845894
    00093165
  • Text Lang
    ja
  • Data Source
    • JaLC
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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