BACTERIOLOGICAL AND MORPHOLOGICAL STUDIES ON ANTIBACTERIAL ACTIVITIES OF DIHYDROXYMETHYL-FURATRIZINE
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- KOIKE MASAATSU
- Department of Microbiology, School of Dentistry, Kyushu University
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- IIDA KYOKO
- Department of Microbiology, School of Dentistry, Kyushu University
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- NAKASHIMA KOICHI
- Department of Microbiology, School of Dentistry, Kyushu University
Bibliographic Information
- Other Title
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- Dihydroxymethyl-furatrizineの抗菌作用と感受性菌の形態変化
- Dihydroxymethyl-furatrizine ノ コウキン サヨウ ト カンジュセイキン ノ ケイタイ ヘンカ
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Abstract
Antibacterial activities of dihydroxymethyl-furatrizine againstEscherichia coli B and Staphylococcus aureus 209 P were investigated and morphological alterations of the drug-treated cells were examined by scanning and transmission electron microscopy. Difference between the action of the drug E.coli and against Staph, aureus was clearly indicated in this experiment : The drug exerts the bactericidal effect on E. coli, but bacteriostatic on Staph. aureus. Further, morphological alterations of the drug-treated cells were also quietly different between both bacteria. After several hours contact with sublethal dose of the drug, the cells of E. coli elongated up to 20-30μ, which was resulted from inhibition of dividing, and partially lysed, while in Staph. aureus, thiny cells with 0.3-0.5μ in diameter were produced by abnormal septation. From these results, the regulatory mechanism of the cell dividing may be possibly affected by this drug.
Journal
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- CHEMOTHERAPY
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CHEMOTHERAPY 22 (7), 1146-1152, 1974
Japanese Society of Chemotherapy
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Details 詳細情報について
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- CRID
- 1390282681256358656
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- NII Article ID
- 130004191543
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- NII Book ID
- AN00186653
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- ISSN
- 18845894
- 00093165
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- NDL BIB ID
- 7494197
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- Data Source
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- JaLC
- NDL
- CiNii Articles
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- Abstract License Flag
- Disallowed