STUDIES ON SUSCEPTIBILITY OF CLINICALLY ISOLATED BACTERIAL STRAINS TO NITROFURAN DERIVATIVES

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  • 各種病巣由来菌に対するNitrofuran剤の感受性分布について
  • カクシュ ビョウソウ ユライキン ニ タイスル Nitrofuran ザイ ノ カンジュ ショウブンフ ニ ツイテ

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Antibacterial activity of Panfuran-S, Panfuran acetate, Panazon, Furazolidone and Furadantin was investigated by using each 100 strains of Shigella, E. coli, Ps. aeruginosa, Proteus, Salmonella and S. aureus which were isolated from clinical specimens.<BR>1. In 5 nitrofuran derivatives, Panfuran-S showed very strong antibacterial activity against bacterial strains tested.<BR>2. Panfuran-S showed strong antibacterial activity against Shigella sonnei, Proteus morganii, and E groups ofSalmonella.<BR>3. The bacterial strains highly resistant to Panfuran-S were not isolated from our survey during 10 years.<BR>4. Cross resistance was observed between nitrofuran derivatives, but not observed between nitrofuran derivatives and TC, CP, SM, SA, KM and ABPC.<BR>5.In vitro developed strains highly resistant to Panfuran-S were not demonstrated so far as examined, and in vitro developed resistance was found to be labile and decreased after several subcultures in nutrient broth.

Journal

  • CHEMOTHERAPY

    CHEMOTHERAPY 22 (7), 1133-1140, 1974

    Japanese Society of Chemotherapy

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