EFFECTS OF AMINOBENZYL PENICILLIN (ABPC) AND AMINOCYCLOHEXYL PENICILLIN (ACPC) ON FECAL FLORA AND CECAL WEIGHTS IN MICE

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  • IMAI AKIHIRO
    Biological Research Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.
  • MORISHITA KEIKO
    Biological Research Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.

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  • Aminobenzyl penicillin (ABPC) およびAminocyclohexyl penicillin (ACPC) 経口投与によるマウスの糞便菌叢の変化および盲腸重量の変化について
  • Aminobenzyl penicillin ABPC オヨビ Aminocy

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Oral administration of ABPC or ACPC to mice resulted in a decrease of the number of cultured fecal bacteria with an increase of cecal weights. These effects were more pronounced in ABPC than in ACPC. Furthermore, in histological examinations of the cecum, Gram-negative tapered rods-fusiform bacteria could hardly be detected in ABPC treated mice, but a small number of these bacteria was observed in ACPC treated mice. Therefore, the difference in the effect on the cecum between both antibiotics is considered to be due to the difference in the number of fusiform bacteria after these treatment.

Journal

  • CHEMOTHERAPY

    CHEMOTHERAPY 23 (10), 3192-3196, 1975

    Japanese Society of Chemotherapy

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