セフメタゾール（ＣＭＺ）の骨関節の感染症に対する治療効果

DOI Web Site

書誌事項

タイトル別名
  • THE EFFECT OF CEFMETAZOLE (CMZ) ON BONE JOINT INFECTION
  • Cefmetazole CMZ ノ コツカンセツ ノ カンセンショウ ニ タイ

この論文をさがす

説明

Cefmetazole (CMZ) was administered to the thirty three cases of infectious diseases of bone and joint. In most of cases, 2.0g of CMZ was solved in 500ml of saline or the similar and intravenously dripped twice a day, taking one or two hrs. Ten cases of acute suppurative osteomyelitis completely healed by mainly general chemotherapy.<BR>Ten of recurrence of chronic osteomyelitis of which symptom was acute inflammation, effectively healed as well. In five cases of chronic osteomyelitis, one case failed in healing because of infection with resistant Serratia, which was finally amputated being due to sinus carcinoma. Five cases of acute suppurative arthritis was similarly treated and effectively healed by mainly chemotherapy. In three cases of chronic arthritis, one individual had hepatitis due to toxicosis by anesthetic drug, so that chemotherapy had to be discontinued. In general, 31 cases of bone and joint infection was satisfactorily healed out of 33 with administration of CMZ.<BR>In this series of infections, causative microorganisms were found to be positive in twenty cases, in which majority of organism was S. aureus as fourteen cases. One case of Serratia was sufficiently suppressed by CMZ, but the other case of Serratia was resistant to CMZ.<BR>Twenty four cases out of all were hematogenous infection and nine were exogenous following to open fracture or iatrogenic disorder. CMZ is known to have broad spectrum antibacterial action and thought to be advantageous as a therapeutic drug of first choice for particularly early treatment of hematogenous osteomyelitis and suppurative arthritis.

収録刊行物

詳細情報 詳細情報について

問題の指摘

ページトップへ