新しい経口用セファロスポリン系抗生物質Cefaclorに関する細菌学的評価

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  • BACTERIOLOGICAL EVALUATION OF CEFACLOR, A NEW ORAL CEPHALOSPORIN ANTIBIOTIC
  • アタラシイ ケイコウヨウ セファロスポリンケイ コウセイ ブッシツ Cefac

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The in vitro and in vivo antibacterial activity of cefaclor (CCL), a new oral cephalosporin antibiotic, was compared with that of cephalexin (CEX). The following results were obtained.<BR>1) CCL showed broad antibacterial spectrum against gram-positive and gram-negative bacteria. The antibacterial activity of CCL was 2 to 8 times superior to that of CEX.<BR>2) Sensitivity distribution of clinical isolates to CCL exhibited 2 to 8 times stronger activity than CEX against S. aureus, E. coli, K. pneumoniae and P. mirabilis.<BR>3) Influence of medium pH and inoculum size on in vitro antibacterial activity of CCL showed the same tendency to CEX. The antibacterial activity of CCL was slightly influenced by the addition of horse serum.<BR>4) The effect of CCL on growth curve of S. aureus, E. coli and K. pneumoniae was also studied. CCL had a stronger bactericidal and lytic activity against E. coli and K. pneumoniae than CEX does.<BR>5) In protective effect studies on experimental mice infected with S. aureus, S. pyogenes, S. pneumoniae, E. coli and K. pneumoniae respectively the activity (ED50) of CCL was 4 to 10 times superior to that of CEX. In E. coli and K. pneumoniae infections with large challenge dose CCL was much more effective than CEX was.

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