Ceftazidime (SN401) の抗菌力とその生体内効果に対する基礎的研究

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タイトル別名
  • BASIC STUDIES ON THE ANTIBACTERIAL ACTIVITY AND <I>IN VIVO</I> EFFICACY OF CEFTAZIDIME (SN401)
  • Ceftazidime SN401 ノ コウキンリョク ト ソノ セイタイナイ

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説明

Ceftazidime (CAZ, SN 401) manifested the most powerful antipseudomonal and antiserratia activities among cephem antibiotics ever known. The drug exhibited strong activities also against S. pyogenes, S. pneumoniae, Klebsiella spp., E. coli, Enterobacter spp., Citrobacter spp., P. mirabilis, P.vulgaris and P. morganii as high as those of other 3rd generation cephems. CAZ was confirmed to be not only stable to various β-lactamases but also possess lower binding affinities to the enzymes, resulting in rare resistant clinical isolates of gram-negative bacteria. The drug possessed the binding affinities to the penicillin-binding proteins (PBPs) 3, 1a, 1b and 2 in order either in E. coli or P. aeruginosa, indicating that the drug may manifest a strong bactericidal effect. Moreover, CAZ demonstrated a marked synergy of bactericidal effect with the serum complement and cultured macrophages derived from ICR mice. The obtained results suggested that CAZ is expected a good in vivo effect.

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