Pipemidic acidに関する研究

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書誌事項

タイトル別名
  • STUDIES ON PIPEMIDIC ACID
  • Pipemidic acid ニカンスルケンキュウ
公開日
1975
DOI
  • 10.11250/chemotherapy1953.23.2808
公開者
公益社団法人 日本化学療法学会

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説明

On a new chemotherapeutic agent, pipemidic acid, some studies were carried out and the following results were obtained.<BR>1. The organ levels following oral administration of pipemidic acid to mice ranked in order of their height, kidneys, liver, lungs and serum.<BR>2. The protein binding rate of pipemidic acid using dialysis against horse serum was the smallest comparing with nalidixic acid and piromidic acid.<BR>3. The serum levels during the consecutive dosings of pipemidic acid to healthy volunteers were maintained regularly. The daily peak level reached about 8 μg/ml in 1 g dosings every 8 hours and 16 μg/ml in 2 g dosings in the same manner.<BR>After one week, transient proteinuria, abdominal fullness and pain, borborygmus and diarrhea were complained in some cases, but all volunteers tolerated well through one week administration.<BR>4. Clinically pipemidic acid was administered to 10 patients with urinary tract infections. The results were as follows : 1 excellent, 5 good, 3 fair and 1 poor. The poor one was chronically affected by Pseudomonas aeruginosa. Besides, one case of cholecystitis was treated and responded well. Side effects were experienced in one case who showed transient diarrhea.

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