Cefoxitinの臨床集計について

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タイトル別名
  • CLINICAL STUDIES ON CEFOXITIN IN JAPAN
  • Cefoxitin ノ リンショウ シュウケイ ニ ツイテ

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説明

A series of clinical studies on cefoxitin, a new cephamycin antibiotic, were conducted by a multi-clinic group of investigators.<BR>An unexpectedly high overall efficacy rate of 74% was obtained inspite of the fact that these studies were done on moderately to severely ill patients, predominantly over 50 years of age, in the fields of internal medicine, surgery, urology and gynecology. In these studies, cefoxitin was administered intravenously in a dose of one or two grams b.i.d. or t.i.d. either by bolus injection or drip infusion.<BR>Excellent therapeutic effects were recognized among patients suffering from respiratory tract, urinary tract and biliary tract infections, and also in septicemia caused by E. coli, Klebsiella, Proteus, Enterobacter, Serratia, etc. It should be emphasized, moreover, that patients who had failed to respond to otherantibiotic treatments responded to cefoxitin with an efficacy rate of 68%.<BR>In view of the results stated above, it can be said that cefoxitin is an antibiotic superior to other antibiotics in the treatment of infections caused by gram-negative bacteria which produce β-lactamase.<BR>If feasible, cefoxitin should be given three times daily but the majority of patients employed in the above studies received it twice daily. Further efforts will be required to accumulate data on patients receiving cefoxitin three times daily.<BR>As for side effects, rash, as an allergic reaction to β-lactam antibiotics, was observed in a few cases, but its frequency was the same as with other cephalosporins. An elevation in transaminase was observed occasionally during cefoxitin treatment, but this also is in common with other β-lactam antibiotics but the reason has not been clarified as yet.

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