Cephalexinの直腸投与法に関する基礎的研究.I

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タイトル別名
  • STUDIES FOR THE RECTAL ADMINISTRATION OF CEPHALEXIN. I
  • Cephalexin ノ チョクチョウ トウヨホウ ニ カンスル キソテキ ケ
  • RECTAL ABSORPTION
  • 直腸吸収について

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抄録

An orally administrable cephalosporin ; Cephalexin could also be administrable through rectum as rectal capsule. That is, absorption of cephalexin through rectum turned out to be as high as that through small intestine. But, there are large amounts of Cephalosporinase-producing Gram-negative bacteria in rectum in contrast of the few Gram-negative rods in small intestine. Therefore, rectal capsule should contain not only cephalexin but also the drugs which inhibit the functions of these bacteria, or neutralize the Caphalosprinase activity produced by these bacteria. The most excellent additive drugs which allow the best rectal absorption of cephalexin could be Cephalosporinase inhibitors which have no antibacterial activity and are not absorbed through intestine.

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