ラットにおける<SUP>3</SUP>H-HBKの生体内動態 (第2報)

DOI

書誌事項

タイトル別名
  • ABSORPTION, DISTRIBUTION, METABOLISM AND EXCRETION OF 31-1-HBK IN RATS II
  • ABSORPTION, DISTRIBUTION, METABOLISM AND EXCRETION AFTER SINGLE INTRAMUSCULAR ADMINISTRATION IN FEMALE RATS AND AFTER MULTIPLE INTRAMUSCULAR ADMINISTRATION IN MALE RATS
  • 雌性ラットにおける筋肉内単回投与後および雄性ラットにおける筋肉内連続投与後の吸収, 分布, 代謝および排泄

抄録

The distribution and placental transfer were studied in pregnant rats after the single intramuscular administration of 3H-HBK at the dose of 2mg potency/kg. The absorption, distribution and excretion of 3H-HBK were also studied in male rats after multiple intramuscular dose (2 mg potency/kg).<BR>1. The radioactive concentration in the fetus was low when 3H-HBK was administered intramuscularly to 13 th-day and 18 th-day pregnant rats.<BR>2. The maximal milk concentration of radioactivity was 0.16μg equivalent of HBK/ml 4 hr after the intramuscular administration of 3H-HBK. The milk levels decreased more slowly thafn the blood levels.<BR>3. The blood level 8 hr after daily dose reached to the steady state around 9 th dose. The blood concentration-time curve until 8 hr after 14 th dose were almost the same as that after first administration.<BR>4. The tissue or organ levels of radioactivity after 14 th dose decreased more slowly than they did after first administration in the most tissues and organs, especially in trachea, adrenal, testis, tpididymis and sudmaxillary gland.

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