肺炎桿菌性マウス実験肺炎を場とするCefazolinによる化学療法の解析

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  • EXPERIMENTAL ANALYSIS OF CEFAZOLIN THERAPY OF MURINE PNEUMONIA DUE TO <I>KLEBSIELLA PNEUMONIAE</I>
  • ハイエン カンキンセイ マウス ジッケン ハイエン オ バ ト スル Cefa

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The therapeutic effects of cefazolin on the murine pneumonia due to Klebsiella pneumoniae have een studied, utilizing the method for quantitating both intrapulmonary viable bacteria and drug mcentrations.<BR>Klebsiella pneumoniae B-54 inhaled and deposited in the lungs of mice diminished during about 6 ours (initial clearance), and then grew rapidly, making pneumonia throughout the lungs, and killed of the mice within 72 hours.(LD50: 9.7×10 C. F. U./lung). Cefazolin therapy was started 12 ours after infection. M. I. C. of cefazolin against this bacteria is 1.56 μg/ml. Single injection of 50-800 mg/kg of cefazolin was not a curative dose. After s. c. injection of 50 mg/kg, the drug levels murine lungs maintained more than 2 M. I. C. s during 1 hour, however, the bacteria in the lungs tarted to grow at 1 hour after injection, excee ding the number of bacteria before injection 2 to 3 ours after injection.<BR>Then repeated s. c. injeetions of 50 mg/kg of cefazolin were examined. Neither injections q. 12 h. or q. 6 h. were curative. Injections q. 3 h. suppressed the bacterial growth in the lungs, but pneu-Ionia did not cured. Injections both q. 2 h. more than 69 times and q. 1 h. 10 times saved all the lice from pneumonia. The number of viable bacteria in lungs did not decrease gradually, but shored a stationary phase despite of continuous chemotherapy.<BR>The significance of experimental pneumonia, as compared with the reports by WOOD et al.(1941-956), in relation to chemotherapy utilizing the bactericidal antibiotic, cefazolin, was discussed.<BR>On the basis of these results, it may be concluded that administration of antibiotics shoud be started s early as possible, and that a dose and the administration frequency of those antibiotics should be ncreased as high as possible considering side effects.

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