STABIHTY OF CEFTEZOLE AGAINST VARIOUS β-LACTAMASES FROM GRAM-POSITIVE AND GRAM-NEGATIVE BACTERIA

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  • NEHASHI TOSHIYUKI
    Department of Bacteriology, School of Medicine, Juntendo University Research Laboratories, Chugai Pharmaceutical Co., Ltd.
  • YAMAMOTO TATSUO
    Department of Bacteriology, School of Medicine, Juntendo University
  • YOKOTA TAKESHI
    Department of Bacteriology, School of Medicine, Juntendo University

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Other Title
  • Ceftezoleの各種β-lactamaseに対する安定性
  • Ceftezole ノ カクシュ ベータ Lactamase ニ タイスル ア

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Abstract

A newly devised cephalosporin-derivative, ceftezole (CTZ), was investigated for its stability to various β-lactamases.<BR>Though about 60% of clinically isolated, ampicillin resistant E. coil and Klebsiella spp. were found to produce penicillinase type β-lactamase mediated by conjugative R plasmids, CTZ was still highly effective against them because of its nonhydrolysable character by such types of β-lactamase.<BR>On the other hand, some strains of Ent. cloacae, Serratia marcescens and Pr. vulgaris were highly resistant not only to penicillins but also cephalosporin derivatives including CTZ. Ent. cloacae Nek-39, one of the resistant strains, was confirmed to produce both plasmid-mediated penicillinase type and chromosomally originated cephalosporinase type f3-lactamases, by means of Sephadex G-75, CM-cellulose and DEAE-cellulose column chromatography. CTZ was tolerant to the former g-lactamase but not to the latter one.<BR>CTZ was not hydrolysed also by penicillinase produced by penicillin G resistant Staph. aureus, and it showed marked antibacterial effect on that.<BR>It may be concluded that CTZ is one of the excellent chemotherapeutics for infectious diseases caused by ampicillin resistant E. coli and Klebsiella, and by penicillin G resistant Staphylococcus as well.

Journal

  • CHEMOTHERAPY

    CHEMOTHERAPY 24 (4), 635-644, 1976

    Japanese Society of Chemotherapy

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