産婦人科領域におけるCeftezoleに関する臨床的検討

張 南薫, 高橋 亨正, 藤山 武久, 小森山 義弘, 木村 武彦, 大沼 靖彦, 國井 勝昭, 斎藤 忠明

doi:10.11250/chemotherapy1953.24.1149

産婦人科領域におけるCeftezoleに関する臨床的検討

DOI Web Site

張南薫

昭和大学医学部産婦人科学教室
高橋亨正

昭和大学医学部産婦人科学教室
藤山武久

昭和大学医学部産婦人科学教室
小森山義弘

昭和大学医学部産婦人科学教室
木村武彦

昭和大学医学部産婦人科学教室
大沼靖彦

昭和大学医学部産婦人科学教室
國井勝昭

國井病院
斎藤忠明

國井病院

書誌事項

タイトル別名

CLINICAL STUDIES ON CEFTEZOLE
サンフジンカリョウイキニオケル Ceftezole ニカンスルリンシ

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抄録

The clinical studies on ceftezole (CTZ), a new derivative of cefazolin, were made in the field of obsterics and gynecology. The results obtained were as follows.<BR>1) The serum levels in 2 patients with normal renal function after intramuscular injection of CTZ were determined. The average peak level of CTZ after a single dose of 500 mg reached more than 201.1g/ml at 30 minutes. The urinary excretion rate in the other patients was about 72% within 6 hours.<BR>2) CTZ was administered at a daily dose of 500 mg to 4 g to 21 patients (7 with urinary tract infections, 5 with wound infection after operation and 5 with the other various infections).<BR>Clinical response was excellent in 3 cases, good in 13, undecided in 2 and poor in3, effectiveness rate being about 76%.<BR>No noteworthy side effect was encountered except one case of elevation of GOT and GPT.