CLINICAL STUDIES OF CEFOTETAN (YM09330) IN SURGICAL FIELD

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  • YAMAMOTO YASUHIRO
    The First Department of Surgery, School of Medicine, Fukuoka University
  • HARADA TOSHIRO
    The First Department of Surgery, School of Medicine, Fukuoka University
  • SHIMURA HIDEHIKO
    The First Department of Surgery, School of Medicine, Fukuoka University

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Other Title
  • 外科領域におけるCefotetan (YM09330) の臨床効果
  • ゲカ リョウイキ ニ オケル Cefotetan YM09330 ノ リンショ

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Abstract

Cefotetan (CTT, YM 09330) was studied in 9 cases of surgical field including 4 cases of infectious cholangitis, each 2 cases of pneumonia and intraabdominal abscess and one case of postoperative wound infection and administered 0.5g or 1.0g twice a day for 4-10 days. The results were good in 8 cases, poor in 1 case with effective rate of 88.9%.<BR>Bacteriological effects with 11 strains in 8 species were as follows; 2 strains of E. coli, each one strain of Klebsiella, H. influenzae, S. epidermidis, α-Streptococcus, Citrobacter and S. paratyphi were eradicated and 1 strain of E. coli decreased but 2 strains of Pseudomonas persisted.<BR>No side effects were observed, and in laboratory findings, no abnormal elevations of transaminase, BUN and creatinine were found.<BR>Thus, cefotetan will be useful drug against infectious diseases in the surgical field.

Journal

  • CHEMOTHERAPY

    CHEMOTHERAPY 30 (Supplement1), 828-831, 1982

    Japanese Society of Chemotherapy

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