ANTIMICROBIAL ACTIVITY IN URINE AND CLINICAL EFFICACY OF CEFTIZOXIME

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  • Ceftizoxime (CZX) の尿中抗菌力と臨床効果
  • Ceftizoxime CZX ノ ニョウチュウ コウキンリョク ト リンショ

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Abstract

Ceftizoxime, a new cephalosporin derivative for parenteral use, was studied both bacteriologically and clinically and following conclusions were obtained.<BR>1) Ceftizoxime showed stronger antimicrobial activity against E. coli, Klebsiella and Serratia than cefazolin.<BR>2) The peak serum levels of 127.3, 63.9 and 25.9 μg/ml were achieved 5 minutes after intravenous injection of 1 g, 0.5 g or 0.25 g of ceftizoxime, and they were dose-dependent.<BR>3) The peak urinary levels of 4, 630, 1, 424 and 585 μg/ml of ceftizoxime were achieved within 2 hours after intravenous injection of the same doses.<BR>4) Antimicrobial activity in urine excreted after administration of ceftizoxime against E. coli, Klebsiella and Serratia was stronger than that of cefazolin.<BR>5) Seven cases with chronic complicated urinary tract infections were treated with ceftizoxime and excellent or moderate responses were obtained in 5 cases.<BR>6) No significant side effects were observed in any of the 7 cases.<BR>7) In conclusion, ceftizoxime was regarded as effective and safe drug in the treatment of urinary tract infections.

Journal

  • CHEMOTHERAPY

    CHEMOTHERAPY 28 (Supplement5), 696-705, 1980

    Japanese Society of Chemotherapy

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