ACQUIREMENT OF RESISTANCE TO CLINDAMYCIN IN <I>BACTEROIDES FRAGILIS</I>. I

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Other Title
  • Clindamycinに対する<I>Bacteroides fragilis</I>の耐性獲得に関する研究第1報
  • Clindamycin ニ タイスル Bacteroides fragilis
  • Appearance of Clindamycin Resistant <I>B. fragilis</I> in Human Feces Administered Clindamycin
  • Clindamycin服用による糞便内のClindamycin耐性<I>Bacteroides fragilis</I>の出現

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Description

A number of clindamycin resistant B. fragilis were isolated from feces of two subjects, who had been administered clindamycin in the past twelve months. These strains showed MIC of 100, μg per ml or more and cross resistance to both lincomycin and erythromycin. In neither of the two subjects without the past experience of clindamycin therapy was there evidence of resistant B. fragilis.<BR>Clindamycin (900 mg per day for a week) was given to a volunteer who had never been administered this drug in the past. Clindamycin resistant strains of B. fragilis were developed in his feces. These strains remained resistance to clindamycin after two years.<BR>It was suggested in this studies that B. fragilis tends to readily acquire drug resistance to clindamycin.

Journal

  • CHEMOTHERAPY

    CHEMOTHERAPY 25 (2), 380-384, 1977

    Japanese Society of Chemotherapy

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