<I>Serratia marcescens</I>に関する実験的化学療法第1報

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タイトル別名
  • EXPERIMENTAL CHEMOTHERAPY AGAINST <I>SERRATIA MARCESCENS</I>. I
  • Serratia marcescens ニ カンスル ジッケンテキ カガク リ
  • <I>In vitro</I> Susceptibility to Antimicrobial Agents
  • 抗菌剤の<I>in vitro</I>感受性

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In vitro susceptibility of 127 clinically isolated strains of Serratia marcescens -87 from the urinary tract (2 chromatogenic), 28 from sputa (13 chromatogenic) and 12 from other sources (6 chromatogenic) -was determined against 21 drugs, i.e., 9 aminoglycoside antibiotics, tetracycline, chloramphenicol, polymyxin B and 3 synthetic antimicrobial agents, according to the method of minimal inhibitory concentration determination specified by the Japan Society of Chemotherapy. Among the aminoglycoside antibiotics, gentamicin showed the most excellent antibacterial activity. By their susceptibility patterns, these antibiotics were classifiable into three groups : gentamicin, KW-1062 and sisomicin ; dibekacin, tobramycin and amikacin ; and streptomycin, kanamycin and lividomycin. Of the synthetic antimicrobial agents, nalidixic acid and pipemidic acid showed good antibacterial activity as did cefoxitin of the cephamycin group among the β-lactam antibiotics. Chloramphenicol and tetracycline yielded resistance in 20% to 30% of the strains and polymyxin B had MICs of >800μg/ml against almost all the strains. Two strains were resistant to gentamicin and cross-resistance between the aminoglycoside antibiotics determined in these two strains indicated that both were susceptible to amikacin and lividomycin but resistant to all the other aminoglycoside antibiotics. Results of susceptibility to gentamicin, dibekacin and nalidixic acid were studied from the standpoint of bacterial red pigment production and source of isolation, and it was found that those strains resistant to all the three drugs were of urinary tract origin and did not produce a red pigment.

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