外科におけるTicarcillinの抗菌力, 吸収・排泄と臨床応用について

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  • ANTIBACTERIAL SPECTRUM, ABSORPTION, EXCRETION OF TICARCILLIN AND ITS CLINICAL APPLICATION TO SURGICAL FIELD
  • ゲカ ニ オケル Ticarcillin ノ コウキンリョク キュウシュウ ハ

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Laboratory and clinical investigations have been carried out on ticarcillin (TIPC) and following conclusions were obtained.<BR>1) Antibacterial spectrum<BR>Antibacterial spectrum of TIPC was almost the same as that of carbenicillin (CBPC).<BR>2) Susceptibility to bacteria isolated from surgical field<BR>TIPC has antibacterial activity against Staphylococccus aureus, Escherichia coli, Pseudomonas aeruginosa. Especially, TIPC was one step superior to CBPC against E. coli and Ps. aeruginosa. But, against Klebsiella pneumoniae the agent has no antibacterial activity.<BR>3) Serum level and urinary excretion<BR>A dose of 2.0 g of TIPC was administered by intravenous injection to determine serum level by cup method and a peak serum level of 342.4 μg/ml on an average at five minutes after administration. As to urinary concentration determined, a peak of 18. 26 mg/ml on an average was exhibited after one hour. Recovery ratio was 90.5% within six hours. TIPC was shown the highest values at 15 minutes in the serum concentration compared with SBPC and CBPC. And TIPC next to SBPC was exhibited a high ratio in the urinary recovery rate within six hours.<BR>4) Tissue concentratiin in rats Group of SD rats received 200 mg/kg of TIPC by intramuscular injection and the levels ranged as muscle in injected site, liver, kidney, serum and spleen tissue in descending order, while muscle in the contrary site, heart, lung and brain was exhibited in a level in order.<BR>5) Results of clinical application<BR>TIPC was applied to two cases of intra-peritoneal abscess and the results were effective in one case and ineffective in the other. As to side effect of the drug, an increase of GOT and GPT values was noticed at third day after administraion, but GOT values returned within normal values after the end of administration.

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