形成外科領域におけるTicarcillinの基礎的・臨床的検討

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  • FUNDAMENTAL AND CLINICAL STUDIES ON TICARCILLIN
  • ケイセイ ゲカ リョウイキ ニ オケル Ticarcillin ノ キソテキ

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Fundamental experiments and clinical studies on ticarcillin were performed, and the following results were obtained.<BR>1) The concentrations of ticarcillin in the skin and serum of rabbits were determined.<BR>(i) Intravenous administration of ticarcillin 100 mg/kg in one shot : <BR>The peak of concentration in serum was 217 μg/ml (mean value) 30 minutes after injection. On the other hand, the peak in skin was 138.1 μg/g (mean value) after 30 minutes. The ratio of concentration in the skin to the serum showed 64%.<BR>(ii) Drip infusion of ticarcillin 100 mg/kg in 1 hour : <BR>The peak of concentration was observed immediately after the administration, both in serum and skin. The ratio of the skin to the serum was 40%.<BR>2) Ticarcillin, 750 mg to 6 g per day, was admininstered to the 12 cases (burned ulcer : 8, ulcer due to traffic accident : 1, post-operative ulcer : 1, decubitus : 1, post-operative pneumonia : 1). Ticarcillin was observed to be effective in 10 cases of 12.<BR>In a few cases, elevation of S-GOT, S-GPT and Al-P were observed, but it was not sure as a result of side effect or not.<BR>3) Minimum inhibitory concentration of ticarcillin against Ps. aeruginosa isolated from the infective ulcers was examined.<BR>Ticarcillin was more effective than carbenicillin, 2-4 times. While in comparison to sulbenicillin, ticarcillin was same or twice in effectiveness.

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