外科領域におけるTicarcillin (TIPC) の基礎的, 臨床的検討

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  • FUNDAMENTAL AND CLINICAL STUDIES ON TICARCILLIN (TIPC) ON SURGICAL FIELD
  • ゲカ リョウイキ ニ オケル Ticarcillin TIPC ノ キソテキ

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The following conclusions were obtained on a new semisynthetic penicillin, ticarcillin (TIPC).<BR>1) Antibacteria activity<BR>The minimum inhibitory concentraion (MIC, μg / ml) of TIPC and carbenicillin (CBPC) was examined against Ps. aeruginosa, E. coli and Klebsiella pneumoniae isolated from surgical lesions. The results demonstrated stronger activity of TIPC against Ps. aeruginosa and E. coli than that of CBPC, same as Kleb. pneumoniae.<BR>2) Absorption and excretion<BR>Biliary excretions and serum levels were measured in rabbits and clinical cases. Bile levels oi TIPC in rabbits were 34.7 μg / ml after 0-1 hours, and that was higher than serum level. In two human clinical cases, bile levels were 15-30, μg / ml after 1-3 hours.<BR>3) Results of clinical applications<BR>TIPC was administered in 9 patients, and the clinical results obtained were excellent in 3, good in 3, fair in 1, poor in 1 and unknown in 1 case, then clinical effective rate was 75%. Bacterial eradicated rate was 85%.<BR>4) No side effect was obtained.

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