複雑性尿路感染症に対するTicarcillinの基礎と臨床

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  • LABORATORY AND CLINICAL INVESTIGATIONS WITH TICARCILLIN IN COMPLICATED INFECTIONS OF URINARY TRACT
  • フクザツセイ ニョウロ カンセンショウ ニ タイスル Ticarcillin

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Laboratory and clinical investigations have been performed on a new antibiotic ticarcillin (TIPC), and the results were obtained as follows.<BR>1. When 1 g of TIPC was administered intravenously to 2 healthy adults, blood levels of the drug were 87.6 pg/ml on the average after 15minutes, and they disappeared after 6 hours. Recovery ratio of the drug in urine was 76.9% within 6 hours.<BR>2. MIC of TIPC was compared with that of CBPC and SBPC on 80 strains of E. coli, 73 strains of S. marcescens and 25 strains of Ps. aeruginosa, each derived from urinary tract infections. E. coli showed no difference among 3 drugs at inoculum size of 108/ml, and yet at 106/ml a peak of CBPC was 12.5 μg/ml, and that of SBPC 6.25 μg/ml, while that of TIPC was 1.56 μg/ml, being 2-3 times superior. S. marcescens showed no difference among 3 drugs at 108/ml too, mostly being >100 μg/ml, while at 106/ml TIPC exhibited a small peak of 12. 5 μg/ml. Ps. aeruginosa showed all >100 μg/ml of CBPC at inoculum size of 108/ml, ≥100μg/ml of SBPC, while 25->100 μg/mi of TIPC, at 106/ml too, CBPC and SBPC were distributed among 25->100 μg/ml, while TIPC among 12. 5->100 μg/ml.<BR>3. TIPC was administered to 32 cases of complicated infection of urinary tract, and the results obtained were excellent effect in 5 cases, good effect in 12 cases, and no effect in 14 cases, effective ratio being 54. 8%. Classified by causative organism, Pseudomonas and E. coli resulted in good result, whereas Serratia poor result.<BR>4. As to the side effect of TIPC, cough was noticed in 1 case, nausea and vomiting in 1 case, local pain in1 case, and elevation of GOT and GPT in 4 cases.

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