泌尿器科領域におけるTicarcillinの基礎的, 臨床的検討

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タイトル別名
  • LABORATORY AND CLINICAL STUDIES ON TICARCILLIN IN URINARY TRACT INFECTIONS
  • ヒニョウキカ リョウイキ ニ オケル Ticarcillin ノ キソテキ リ

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1. Minimal inhibitory concentrations of ticarcillin, carbenicillin (CBPC) and sulbenicillin (SBPC) were determined by the plate dilution method against 48 strains of Ps. aeruginosa isolated from infected urine.<BR>In vitro antibacterial activities of ticarcillin varied with inoculum size. Its activities with 106 cells/ml inoculum size were more potent than 108 cells/ml. With 106 cells/ml of inoculum size, ticarcillin was 2 to 4 times more active than CBPC or SBPC against Ps. aeruginosa, 28 out of 48 strains (58.3%) being inhibited by concentration of 50 μg/ml or less.<BR>2. Ticarcillin was administered parenterally at a dose of 1 g twice a day for 7 days to 10 patients with chronic urinary tract infection.<BR>Results obtained were good in 5 cases, fair in 1 case and poor in 4 cases. The medication was well tolerated with no side effects.

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