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- SHIMAZU RYOICHI
- Department of Urology, Gifu University, School of Medicine
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- KATO NAOKI
- Department of Urology, Gifu University, School of Medicine
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- KAWADA YUKIMICHI
- Department of Urology, Gifu University, School of Medicine
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- NISHIURA TSUNEO
- Department of Urology, Gifu University, School of Medicine
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- MIYAMURA RYUZO
- Department of Urology, Saitama Chuo Hospital of Social Health Insurance
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- TAHARA TATSUO
- Department of Urology, Tokyo Metropolitan Toshima Hospital
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- NISHIMURA YOJI
- Department of Urology, Mitsui Memorial Hospital
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- SAITO ISAO
- Department of Urology, Tokyo Kyosai Hospital
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- SHIMIZU YASUO
- Department of Urology, Gifu Prefectural Gero Onsen Hospital
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- ISOGAI KAZUTOSHI
- Department of Urology, Ogaki City Hospital
Bibliographic Information
- Other Title
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- Ticarcillinの基礎的・臨床的検討
- Ticarcillin ノ キソテキ リンショウテキ ケントウ
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Abstract
Laboratory and clinical investigations were performed on a new synthetic penicillin, ticarcillin (TIPC), and the following conclusions were obtained.<BR>1. Antibacterial activity of TIPC against 40 strains of Ps. aeruginosa derived from urinary tract, was about 2 times stronger than that of SBPC. Antibacterial activity of CEZ against ABPC resistant E. coil, was superior to that of TIPC, and yet 25% of the strains showed MIC of TIPC ≤ 50μg/ml, while MIC of CEZ≥ 100 μg/ ml.<BR>2. Growth inhibitory effect of TIPC against Ps. aeruginosa, was found in concentration of 1-2MIC, and this remained perfectly for 24 hours.<BR>3. Clinical investigation was made on 40 cases of chronic urinary tract infection. As the results, overall efficacy rate was 38.9% in 18 cases judged on 3rd day, 51.5% in 33 cases judged on 5th day, and 53.8% in 39 cases judged on 7th day. Overall efficacy rate was 50.0% in 22 cases administered a daily dose of 2 g, and 58. 8% in 17 cases administered 3 g. As to the cases under catheterization, efficacy was better at a daily dose of 3 g.<BR>4. As for the side effect, eruption was observed only in 1 case out of all 43 cases treated. As to the laboratory test values, GOT and GPT were elevated slightly only in 1 case.
Journal
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- CHEMOTHERAPY
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CHEMOTHERAPY 25 (9), 2809-2820, 1977
Japanese Society of Chemotherapy
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Details 詳細情報について
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- CRID
- 1390282681259808384
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- NII Article ID
- 130004071154
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- NII Book ID
- AN00186653
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- ISSN
- 18845894
- 00093165
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- NDL BIB ID
- 1914891
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- Data Source
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- JaLC
- NDL
- CiNii Articles
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- Abstract License Flag
- Disallowed