緑膿菌による慢性複雑性尿路感染症に対するTicarcillinとSulbenicillinの二重盲検法による効果の比較

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  • A DOUBLE BLIND CONTROLLED STUDY TO COMPARE TICARCILLIN AND SULBENICILLIN IN THE TREATMENT OF CHRONIC COMPLICATED URINARY TRACT INFECTIONS DUE TO <I>PSEUDOMONAS AERUGINOSA</I>
  • リョクノウキン ニヨル マンセイ フクザツセイ ニョウロ カンセンショウ ニ

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For the purpose of evaluating objectively the treatment efficacy and side effect of ticarcillin (TIPC) in pseudomonal infections of urinary tract, this antibiotic was administered clinically at a daily dose of 2 g to chronic complicated urinary tract infections due to Ps. aeruginosa in adults, and the comparative investigations were performed by double blind method, using SBPC (4 g daily) as control, and the following conclusions were obtained.<BR>1. Among total 120 cases treated, 29 cases were excluded, and 1 case was dropped out. Background factors were investigated between two drug groups on the remaining 90 cases (TIPC 45 cases, and SBPC 45 cases). As the result, no significant difference was found, and the two drug groups were nearly homogeneous. <BR>2. As to the overall clinical effects, excellent rate was 2.2% in TIPC group, while 6. 7% in SBPC group, and excellent plus good rate was 35.6% both in TIPC group and SBPC group, showing thus no significant difference between two groups. Effects on pyuria, bacteriuria, and subjective symptom exhibited similarly no significant difference. <BR>3. Investigations of bacteriological effects showed that eradicated rate of Ps. aeruginosa was 40% in TIPC group, while 42% in SBPC group, exhibiting thus no difference between two groups. <BR>4. Side effects were investigated on 45 cases of TIPC group and 46 cases of SBPC group, and no subjective side effects were noticed in any case of two groups. Abnormalities of laboratory test values were observed only in 1 case of TIPC group (transient elevation of GOT and GPT) and in 1 case of SBPC group (transient elevation of Al-Pase).<BR>From the above results, TIPC may be considered to be a useful drug in the treatment of pseudomonal urinary tract infections.

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