FUNDAMENTAL STUDIES AND CLINICAL EVALUATION OF TICARCILLIN ON URINARY TRACT INFECTION

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  • 尿路感染症におけるTicarcillinの基礎的・臨床的検討
  • ニョウロ カンセンショウ ニ オケル Ticarcillin ノ キソテキ リ

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Abstract

Ticarcillin 1 g was intravenously administered in 4 volunteers. The highest peak of the serum level reached 66. 5 μg/ml at 30 minutes after the injection. Urinary recovery up to 6 hours was measured at 81. 9%.<BR>MICs of ticarcillin against 117 strains of Ps. aeruginosa isolated from patients with urinary tract infections revealed one-half of those of CBPC.<BR>Ticarcillin 1 g i. v. or d. i. was given twice a day for 4-7 days to 26 cases of urinary tract infections including 5 cases of acute pyelonephritis, 5 cases of chronic pyelonephritis and 16 cases of chronic complicated cystitis. Excellent clinical results were obtained in 4 cases and good in a case of acute pyelonephritis respectively. <BR>Out of 21 cases of chronic complicated infections, evaluation was good in 4 cases and failed in 17 cases. No unfavorable side effect was observed except that 3 cases complained of transient nausea which disappeared by slow speed injection. Slight elevation of GOT and GPT was marked in one case respectively, although these cases had been received antitumor agents.

Journal

  • CHEMOTHERAPY

    CHEMOTHERAPY 25 (9), 2873-2882, 1977

    Japanese Society of Chemotherapy

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