Ticarcillinにかんする臨床的研究

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タイトル別名
  • CLINICAL STUDIES ON TICARCILLIN
  • Ticarcillin ニ カンスル リンショウテキ ケンキュウ

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Ticarcillin was studied on its antibacterial activity, absorption, excretion and clinical effects, and the following results were obtained.<BR>1. Antibacterial activity<BR>The antibacterial activities of ticarcillin against E. coli and Pr. mirabilis were 2 to 8 times stronger than those of ampicillin and carbenicillin.<BR>With an inoculum size of 106 cells/ml, ticarcillin was at least two fold more active against Ps. aeruginosa than sulbenicillin and carbenicillin, 76% of isolates being inhibited by 50 pag/ml or less.<BR>2. Absorption and excretion<BR>After a single intramuscular dose of 0.5 and 1.0 g to 6 healthy adults, the mean peak concentrations of ticarcillin in serum were 14. 8 and 28.8 μg/ml respectively at 30 minutes. The biological half life of ticarcillin ranged 0.87 to 1. 18 hours. Ninety-four to 75% of the dose was excreted in the urine during the first 6 hours after injection.<BR>A dose response was obtained with increasing dosage of ticarcillin.<BR>The serum levels of ticarcillin maintained longer in patients with renal insufficiency.<BR>3. Clinical results<BR>Ticarcillin was clinically applied to 20 patients with bacterial infection, including 9 cases of respiratory tract infection, 5 cases of biliary tract infection and 6 cases of urinary tract infection, and the results obtained were good in 15 cases, fair in 1 case, and poor in 4 cases.<BR>No marked side effects were observed.

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