内科領域におけるTicarcillin (TIPC) の基礎的・臨床的検討

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  • LABORATORY AND CLINICAL STUDIES ON TICARCILLIN (TIPC) IN THE FIELD OF INTERNAL MEDICINE
  • ナイカ リョウイキ ニ オケル Ticarcillin TIPC ノ キソテキ

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(1) Antimicrobial activity of ticarcillin (TIPC) against clinically isolatedPs. aeruginosa, E. coli, Kleb.pneumoniaeandStaph. aureus was compared with that of sulbenicillin (SBPC), carbenicillin (CBPC) and ampicillin (ABPC). As the result, TIPC showed better antimicrobial activity againstPs. aeruginosathan SBPC and CBPC.<BR>(2) Intravenous drip infusion of 2 grams of TIPC was done in 2 cases (the one has slight renal impairment, the other has none). Maximal serum concentration of TIPC at the end of drip infusion were 74 μg/ml, 110 μg/ml and urinary excretion rates in 6 hours were 27. 1%, 47. 3% respectively. T112 (half-life time) was around 1 hour.<BR>(3) Two grams of TIPC were administered twice a day to 8 cases including pneumonia (4 cases), pyelonephritis (2 cases), gangrene (1 case) and enteritis (1 case). The clinical results were as follows : excellent in 1, good in 5, fair in 1 and undetermined in 1 case.<BR>(4) No side effect was found including laboratory findings of urine, peripheral blood, renal and hepatic functions.

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