Ticarcillinにかんする基礎的ならびに臨床的研究

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タイトル別名
  • LABORATORY AND CLINICAL STUDIES ON TICARCILLIN
  • Ticarcillin ニ カンスル キソテキ ナラビニ リンショウテキ ケン

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Laboratory and clinical studies were performed on ticarcillin, a new semi-synthetic penicillin with broad antibacterial spectrum, and the following results were obtained.<BR>1) As to the distribution of ticarcillin sensitivity in clinical isolates, a peak was 6.25 pg/ml for Staph. aureus, 6.25 μg/ml and more than 100 μg/ml for E. coli, more than 100 μg/ml for Klebsiella, 0.78 μ/ml for Proteus sp., and 50 μg/ml for Pseudomonas aeruginosa. When the inoculum size was decreased, a peak of sensitivity moved to 3. 12 μg/ml for Staph. aureus, 3. 12 μg/ml and more than 100 μg/ml for E. coli, and 25μg/ml for Pseudomonas aeruginosa.<BR>Compared these antibacterial activities of ticarcillin with those of CBPC, no wide difference was observed for Staph. aureus, Klebsiella and Proteus sp., while the antibacterial activity of ticarcillin was 2 times stronger than that of CBPC for sensitive E. coli and Pseudomonas aeruginosa.<BR>2) Ticarcillin was adminstered intravenously by drip infusion of a daily dose of 2-10g to 5 cases of respiratory tract infection and 2 cases of urinary tract infection each due to Pseudomonas aeruginosa, 7 cases in total. The clinical effects obtained were good in 4 cases and failure in 3 cases. As to the bacteriological effect, Pseudomonas aeruginosa was eradicated in 5 cases out of 7 cases. As to the side effects, epigastric malaise, and phlebitis at injected site were observed each in 1 case.

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