CLINICAL EFFECT OF TICARCILLIN IN ACUTE EXACERBATION OF CHRONIC BRONCHITIS (COMPLICATED WITH PANBRONCHIOLITIS)

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  • 慢性気管支炎 (汎細気管支炎合併) の急性増悪に対するTicarcillinの臨床効果
  • マンセイ キカンシエン(ハンサイキカンシエン ガッペイ)ノ キュウセイ ゾウアク ニ タイスル Ticarcillin ノ リンショウ コウカ

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Abstract

Ticarcillin was administered at a daily dose of 2-12 g for 8-38 days to 15 cases of acute exacerbation of chronic bronchitis complicated with chronic panbronchiolitis.<BR>As to the global effects classified by causative organism, 12 cases of Ps. aerugionosa resulted in excellent effect in 3 cases, good effect in 3 cases, and no effect in 6 cases, and 2 cases of Klebsiella and 1 case of Enterobacter excellent effect. As to the effects classified by dose, cases ofPs. aeruginosa (majority of the cases) resulted in no effect in all 3 cases at a daily dose of 2-3 g, while no effect in 1 case out of 9 cases at a dose of more than 4 g. Ticarcillin should be administered thus at a daily dose of more than 4 g, more than 10 g if possible, to chronic bronchitis complicated with chronic panbronchiolitis due to Pseudomonas.<BR>As for the side effect of the antibiotic, no finding was found by ticarcillin administration except that a transient eosinophilia was noticed in 1 case.

Journal

  • CHEMOTHERAPY

    CHEMOTHERAPY 25 (9), 2604-2608, 1977

    Japanese Society of Chemotherapy

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