新合成経口抗菌剤DL-8280の新鮮臨床分離株に対する<I>in vitro</I>抗菌作用

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  • THE <I>IN VITRO</I> ACTIVITY OF DL-8280 AGAINST CLINICAL ISOLATES OF GRAM-POSITIVE AND NEGATIVE BACTERIA

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The in vitro activity of DL-8280 was compared with the activities of norfloxacin (NFLX), pipemidic acid (PPA), piromidic acid (PA) and nalidixic acid (NA) against clinical bacterial isolates. DL-8280 was found to be 10-100 times more active than PPA, PA or NA against S. aureus and S. faecalis. NFLX was also active, but slightly less active than DL-8280.<BR>Against E. coli, P. aeruginosa and S. marcescens, DL-8280 was more active than PPA, PA or NA, but slightly less active than NFLX. The growth of N. gonorrhoeae including penicillin resistant strains were completely inhibited by≤0.10μ/ml of DL-8280.

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