書誌事項
- タイトル別名
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- EXPERIMENTAL AND CLINICAL STUDIES OF CEFSULODIN (SCE-129) IN PATIENTS WITH <I>PSEUDO MONAS</I> INFECTIONS OF URINARY TRACT
- リョクノウキン ニヨル フクザツセイ ニョウロ カンセンショウ ニ タイスル
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Cefsulodin (SCE-129, CFS), a new cephalosporin derivative synthesized in Japan, was evaluated experimentally and clinically. The results obtained were as follows:<BR>1) Minimal inhibitory concentrations of CFS, sulbenicillin (SBPC) and gentamicin (GM) were determined against 18 clinical isolates of Pseudomonas aeruginosa. CFS was more active than SBPC or GM.<BR>2) CFS was administered intramuscularly at a single dose of 250 mg to 2 male healthy volunteers and 6 patients with normal or impaired renal function. The serum and urinary concentrations were assayed by cup method during 6 hours after administration. The serum concentrations showed peak at 1 hour after injection in all cases. The half-life of CFS was calculated for 1.3 hours in the volunteers, and became prolonged as the renal function fell.<BR>Seventy-six per cent of administered dose was excreted in the urine during the first 6 hours of administration.<BR>3) Twelve patients with Pseudomonas infection of urinary tract were given CFS intramuscularly in daily dose of 500 mg twice a day for 7 days. The clinical results obtained were excellent in 2 cases (16 7%), good in 1 case (8.3%) and poor in 9 cases (75.0%).<BR>4) No marked side effects were observed.
収録刊行物
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- CHEMOTHERAPY
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CHEMOTHERAPY 27 (Supplement2), 317-324, 1979
公益社団法人 日本化学療法学会
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詳細情報 詳細情報について
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- CRID
- 1390282681260174336
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- NII論文ID
- 130004192590
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- NII書誌ID
- AN00186653
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- ISSN
- 18845894
- 00093165
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- NDL書誌ID
- 2081836
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- データソース種別
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- JaLC
- NDL
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可